Welcome to Dr. Hao Sun's Bioinformatics Lab!

The main research interests of our lab is developing bioinformatics solutions for medicinal/biological problems. It is interdisciplinary in nature with a complement of experimental investigation. More specifically, we are focusing on applying computational algorithms and statistical methods on Next Generation Sequencing (NGS) data to (i) facilitate the development of novel diagnostic methods for the Non-Invasive Prenatal Diagnosis (NIPD) and (ii) decipher the transcriptional regulatory codes involving key transcription factors and non-coding RNAs in eukaryotic genomes by working closely with bench-scientists.

Since the establishment of the lab in 2009, we had published more than 30 peer-reviewed papers in high profile journals, such as Science Translational Medicine, PNAS, EMBO Journal, Nucleic Acids Research, Cancer Research, and Bioinformatics. We have developed a series of algorithms to analyze NGS data from transcriptome sequencing data (iSeeRNA & Sebnif suite, NAMS) and bisulfite sequencing data (Methy-Pipe, BSviewer) as well as other software (FetalQuant, FEMER and ODS) and databases (YY1TargetDB, mTFkb).

In collaboration with clinical researchers and bench scientist, we used these algorithms to gain novel biological insights from various biological processes and facilitate the development of cutting-edge NGS-based molecular diagnosis methods especially in NIPD.

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Publication News

Welcome new members: Ms Huang and Mr Ding!

New positions available. See Positions page for detailed information.

Jan 6, 2018: FEMER paper is accepted to Prenatal Diagnosis.

Aug 8, 2017: BSviewer paper is published on Bioinformatics.

Apr 10, 2017: LncFunNet paper is published on Nucleic Acid Research.